CHMP6

Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.^[5][6][7] It is one of charged multivesicular body proteins and a part of endosomal sorting complexes required for transport-III (ESCRT-III) complex.

CHMP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K3W, 3HTU
Identifiers
Aliases	CHMP6, VPS20, charged multivesicular body protein 6
External IDs	OMIM: 610901; MGI: 3583942; HomoloGene: 11607; GeneCards: CHMP6; OMA:CHMP6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 80,991,598 bp[1] End 81,009,517 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 119,804,267 bp[2] End 119,810,374 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle muscle of thigh mucosa of transverse colon monocyte granulocyte right lobe of liver sural nerve stromal cell of endometrium ectocervix Top expressed in right kidney saccule otic vesicle yolk sac otic placode spermatocyte proximal tubule duodenum human kidney lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding protein-containing complex binding Cellular component ESCRT III complex cytosol endosome membrane late endosome membrane endosome membrane extracellular exosome endomembrane system Biological process viral life cycle nucleus organization regulation of exosomal secretion multivesicular body assembly ESCRT III complex assembly endosomal transport protein transport septum digestion after cytokinesis mitotic metaphase plate congression vacuolar transport macroautophagy negative regulation of epidermal growth factor-activated receptor activity transport regulation of protein catabolic process midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79643 208092 Ensembl ENSG00000176108 ENSMUSG00000025371 UniProt Q96FZ7 P0C0A3 RefSeq (mRNA) NM_024591 NM_001085498 RefSeq (protein) NP_078867 NP_001078967 Location (UCSC) Chr 17: 80.99 – 81.01 Mb Chr 11: 119.8 – 119.81 Mb PubMed search [3] [4]
Wikidata
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See also

• Multivesicular body