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CHRNA10

Protein-coding gene in humans From Wikipedia, the free encyclopedia

CHRNA10
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Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

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This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[6] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[7]

α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.

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