CHRNA2

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene.^[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

CHRNA2
Identifiers
Aliases	CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
External IDs	OMIM: 118502; MGI: 87886; HomoloGene: 20193; GeneCards: CHRNA2; OMA:CHRNA2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 27,459,756 bp[1] End 27,479,883 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.36 cM Start 66,372,488 bp[2] End 66,390,397 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad lateral nuclear group of thalamus secondary oocyte prostate prefrontal cortex inferior ganglion of vagus nerve right frontal lobe periodontal fiber renal medulla bone Top expressed in neural layer of retina granulocyte muscle of thigh proximal tubule superior frontal gyrus dentate gyrus of hippocampal formation granule cell thoracic diaphragm cerebellar cortex primary visual cortex lobe of prostate More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine binding acetylcholine receptor activity ion channel activity extracellular ligand-gated ion channel activity ligand-gated ion channel activity acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity Cellular component integral component of membrane acetylcholine-gated channel complex postsynaptic membrane membrane plasma membrane synapse cell junction cell periphery integral component of plasma membrane neuron projection Biological process protein heterooligomerization response to nicotine synaptic transmission, cholinergic ion transport neuromuscular synaptic transmission signal transduction regulation of postsynaptic membrane potential excitatory postsynaptic potential ion transmembrane transport chemical synaptic transmission regulation of membrane potential nervous system process transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1135 110902 Ensembl ENSG00000120903 ENSMUSG00000022041 UniProt Q15822 Q91X60 RefSeq (mRNA) NM_000742 NM_001282455 NM_001347705 NM_001347706 NM_001347707 NM_001347708 NM_144803 RefSeq (protein) NP_000733 NP_001269384 NP_001334634 NP_001334635 NP_001334636 NP_001334637 NP_659052 Location (UCSC) Chr 8: 27.46 – 27.48 Mb Chr 14: 66.37 – 66.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Knockout of this gene in mice potentiates nicotine-modulated behaviors.^[7] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. ^[8]

See also

• Nicotinic acetylcholine receptor