CHRNA3

Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene.^[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). Research with mecamylamine in animals has implicated alpha-3-containing nAChRs in the abusive and addictive properties of ethanol.

CHRNA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZK4
Identifiers
Aliases	CHRNA3, LNCR2, NACHRA3, PAOD2, cholinergic receptor nicotinic alpha 3 subunit, BAIPRCK
External IDs	OMIM: 118503; MGI: 87887; HomoloGene: 591; GeneCards: CHRNA3; OMA:CHRNA3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 78,593,052 bp[1] End 78,621,295 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 54,917,395 bp[2] End 54,933,846 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium thymus gonad buccal mucosa cell secondary oocyte testicle muscle layer of sigmoid colon lateral nuclear group of thalamus appendix rectum Top expressed in lumbar spinal ganglion habenula superior cervical ganglion pineal gland neural tube adrenal gland gray matter layer of cerebellum stellate ganglion trigeminal ganglion embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity ligand-gated ion channel activity extracellular ligand-gated ion channel activity acetylcholine binding acetylcholine receptor activity transmembrane signaling receptor activity protein binding acetylcholine-gated cation-selective channel activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction dendrite acetylcholine-gated channel complex postsynaptic density soma integral component of plasma membrane neuron projection plasma membrane raft Biological process locomotory behavior regulation of smooth muscle contraction regulation of membrane potential regulation of acetylcholine secretion, neurotransmission synaptic transmission, cholinergic ion transport cation transmembrane transport nervous system development behavioral response to nicotine regulation of dendrite morphogenesis synaptic transmission involved in micturition excitatory postsynaptic potential transport activation of transmembrane receptor protein tyrosine kinase activity signal transduction ion transmembrane transport chemical synaptic transmission neuromuscular synaptic transmission response to nicotine nervous system process acetylcholine receptor signaling pathway response to acetylcholine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1136 110834 Ensembl ENSG00000080644 ENSMUSG00000032303 UniProt P32297 Q8R4G9 RefSeq (mRNA) NM_000743 NM_001166694 NM_145129 RefSeq (protein) NP_000734 NP_001160166 NP_660111 Location (UCSC) Chr 15: 78.59 – 78.62 Mb Chr 9: 54.92 – 54.93 Mb PubMed search [3] [4]
Wikidata
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Interactive pathway map

[[File: [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] |alt=Nicotine Activity on Chromaffin Cells edit]] Nicotine Activity on Chromaffin Cells edit

[[File: [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] [[ ]] |alt=Nicotine Activity on Dopaminergic Neurons edit]] Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor