CHRNB3

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.^[5][6] This gene has been identified as a candidate for predisposition to tobacco dependence.

CHRNB3
Identifiers
Aliases	CHRNB3, cholinergic receptor nicotinic beta 3 subunit
External IDs	OMIM: 118508; MGI: 106212; HomoloGene: 36035; GeneCards: CHRNB3; OMA:CHRNB3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 42,697,366 bp[1] End 42,737,407 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 27,858,739 bp[2] End 27,889,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pancreatic ductal cell mucosa of ileum tibialis anterior muscle right testis cerebellar cortex cerebellar hemisphere left testis prefrontal cortex substantia nigra Top expressed in neural layer of retina inner nuclear layer ganglion cell layer habenula outer nuclear layer ventral tegmental area primary visual cortex spinal ganglia meninges superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function channel activity ion channel activity extracellular ligand-gated ion channel activity ligand-gated ion channel activity acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity acetylcholine binding acetylcholine receptor activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction acetylcholine-gated channel complex dopaminergic synapse integral component of plasma membrane neuron projection Biological process response to nicotine synaptic transmission, cholinergic ion transport neuromuscular synaptic transmission signal transduction regulation of postsynaptic membrane potential excitatory postsynaptic potential cation transmembrane transport ion transmembrane transport regulation of synaptic vesicle exocytosis chemical synaptic transmission regulation of membrane potential nervous system process protein heterooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1142 108043 Ensembl ENSG00000147432 ENSMUSG00000031492 UniProt Q05901 Q8BMN3 RefSeq (mRNA) NM_000749 NM_001347717 NM_027454 NM_173212 RefSeq (protein) NP_000740 NP_001334646 NP_081730 NP_775304 Location (UCSC) Chr 8: 42.7 – 42.74 Mb Chr 8: 27.86 – 27.89 Mb PubMed search [3] [4]
Wikidata
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See also

• Nicotinic acetylcholine receptor