CHST11

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.^[5][6]

CHST11
Identifiers
Aliases	CHST11, C4ST, C4ST-1, C4ST1, HSA269537, carbohydrate (chondroitin 4) sulfotransferase 11, carbohydrate sulfotransferase 11, OCBMD
External IDs	OMIM: 610128; MGI: 1927166; HomoloGene: 56808; GeneCards: CHST11; OMA:CHST11 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 104,455,295 bp[1] End 104,762,014 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 82,821,332 bp[2] End 83,031,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia blood cartilage tissue monocyte bone marrow cells ventricular zone granulocyte amniotic fluid trabecular bone internal globus pallidus Top expressed in cumulus cell molar fossa medial dorsal nucleus condyle vestibular membrane of cochlear duct substantia nigra subiculum median eminence arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylgalactosamine 4-O-sulfotransferase activity N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity chondroitin 4-sulfotransferase activity Cellular component Golgi apparatus membrane Golgi membrane integral component of membrane Biological process embryonic skeletal system morphogenesis chondrocyte development embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of transforming growth factor beta receptor signaling pathway post-embryonic development respiratory gaseous exchange by respiratory system cartilage development developmental growth regulation of cell population proliferation embryonic limb morphogenesis polysaccharide localization post-anal tail morphogenesis embryonic viscerocranium morphogenesis carbohydrate biosynthetic process chondroitin sulfate biosynthetic process chondroitin sulfate metabolic process carbohydrate metabolic process proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50515 58250 Ensembl ENSG00000171310 ENSMUSG00000034612 UniProt Q9NPF2 Q9JME2 RefSeq (mRNA) NM_018413 NM_001173982 NM_021439 RefSeq (protein) NP_001167453 NP_060883 NP_060883.1 NP_067414 Location (UCSC) Chr 12: 104.46 – 104.76 Mb Chr 10: 82.82 – 83.03 Mb PubMed search [3] [4]
Wikidata
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Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.^[7]