CHST6

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.^[5][6][7]

CHST6
Identifiers
Aliases	CHST6, MCDC1, carbohydrate sulfotransferase 6, GST4-beta, gn6st-5, hCGn6ST, glcNAc6ST-5, C-GlcNAc6ST
External IDs	OMIM: 605294; MGI: 1931825; HomoloGene: 56927; GeneCards: CHST6; OMA:CHST6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.1 Start 75,472,052 bp[1] End 75,495,445 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 112,615,768 bp[2] End 112,637,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell nasal epithelium tibia mucosa of paranasal sinus olfactory zone of nasal mucosa trachea external globus pallidus inferior ganglion of vagus nerve subthalamic nucleus pars reticulata Top expressed in vestibular sensory epithelium utricle trachea cornea iris vestibular membrane of cochlear duct trigeminal ganglion lumbar spinal ganglion stria vascularis superior cervical ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function sulfotransferase activity transferase activity N-acetylglucosamine 6-O-sulfotransferase activity Cellular component Golgi apparatus Golgi membrane membrane integral component of membrane trans-Golgi network Biological process sulfur compound metabolic process keratan sulfate biosynthetic process N-acetylglucosamine metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4166 56773 Ensembl ENSG00000183196 ENSMUSG00000031952 UniProt Q9GZX3 Q9QUP4 RefSeq (mRNA) NM_021615 NM_019950 RefSeq (protein) NP_067628 NP_064334 Location (UCSC) Chr 16: 75.47 – 75.5 Mb Chr 8: 112.62 – 112.64 Mb PubMed search [3] [4]
Wikidata
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It codes for an enzyme necessary for the production of keratan sulfate. Mutations in the gene lead to macular corneal dystrophy.