CIDEB

Protein-coding gene in humans From Wikipedia, the free encyclopedia

CIDEB

Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.[5][6][7]

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CIDEB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCIDEB, cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b
External IDsOMIM: 604441; MGI: 1270844; HomoloGene: 7666; GeneCards: CIDEB; OMA:CIDEB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014430
NM_001318807

NM_009894
NM_026804

RefSeq (protein)

NP_001305736
NP_055245

NP_034024

Location (UCSC)Chr 14: 24.31 – 24.31 MbChr 14: 55.99 – 56 Mb
PubMed search[3][4]
Wikidata
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In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[8] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[9] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[10][8]

References

Further reading

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