CIDEB

Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.^[5][6][7]

CIDEB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D4B
Identifiers
Aliases	CIDEB, cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b
External IDs	OMIM: 604441; MGI: 1270844; HomoloGene: 7666; GeneCards: CIDEB; OMA:CIDEB - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,305,096 bp[1] End 24,311,430 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,991,507 bp[2] End 55,995,915 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum spleen granulocyte monocyte blood mucosa of esophagus human kidney left adrenal cortex right adrenal gland Top expressed in right kidney jejunum human kidney duodenum left lobe of liver ileum proximal tubule intestinal villus epithelium of small intestine colon More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding Cellular component perinuclear region of cytoplasm cytosol lipid droplet intracellular anatomical structure Biological process positive regulation of release of cytochrome c from mitochondria execution phase of apoptosis activation of cysteine-type endopeptidase activity positive regulation of cell death intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27141 12684 Ensembl ENSG00000136305 ENSG00000285199 ENSMUSG00000022219 UniProt Q9UHD4 O70303 RefSeq (mRNA) NM_014430 NM_001318807 NM_009894 NM_026804 RefSeq (protein) NP_001305736 NP_055245 NP_034024 Location (UCSC) Chr 14: 24.31 – 24.31 Mb Chr 14: 55.99 – 56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.^[8] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.^[9] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.^[10][8]