CILP

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.^[5][6][7]

CILP
Identifiers
Aliases	CILP, CILP-1, HsT18872, cartilage intermediate layer protein
External IDs	OMIM: 603489; MGI: 2444507; HomoloGene: 2679; GeneCards: CILP; OMA:CILP - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,194,760 bp[1] End 65,211,473 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 65,172,462 bp[2] End 65,187,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii synovial joint pericardium subcutaneous adipose tissue skin of hip thoracic diaphragm gallbladder decidua tibia Top expressed in ankle intercostal muscle sciatic nerve lip soleus muscle epithelium of lens esophagus medial head of gastrocnemius muscle temporal muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide diphosphatase activity alkaline phosphatase activity extracellular matrix structural constituent Cellular component extracellular region extracellular matrix extracellular exosome extracellular space collagen-containing extracellular matrix Biological process negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of gene expression dephosphorylation negative regulation of SMAD protein signal transduction cellular response to transforming growth factor beta stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8483 214425 Ensembl ENSG00000138615 ENSMUSG00000042254 UniProt O75339 Q66K08 RefSeq (mRNA) NM_003613 NM_173385 NM_001364527 RefSeq (protein) NP_003604 NP_775561 NP_001351456 Location (UCSC) Chr 15: 65.19 – 65.21 Mb Chr 9: 65.17 – 65.19 Mb PubMed search [3] [4]
Wikidata
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Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.^[7]