CITED2

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.^[5][6][7]

CITED2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P4Q, 1R8U
Identifiers
Aliases	CITED2, ASD8, MRG-1, MRG1, P35SRJ, VSD2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
External IDs	OMIM: 602937; MGI: 1306784; HomoloGene: 4433; GeneCards: CITED2; OMA:CITED2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.1 Start 139,371,807 bp[1] End 139,374,648 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A2 Start 17,598,966 bp[2] End 17,601,422 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium beta cell gastric mucosa left ovary right ovary nipple decidua left uterine tube right lung Skeletal muscle tissue of rectus abdominis Top expressed in medullary collecting duct renal corpuscle left lung lobe primitive streak lobe of cerebellum habenula decidua cerebellar vermis vestibular membrane of cochlear duct retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription corepressor activity DNA-binding transcription factor activity chromatin binding LBD domain binding protein binding histone acetyltransferase binding protein domain specific binding Cellular component cytoplasm nucleus nucleoplasm protein-containing complex Biological process nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry adrenal cortex formation positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation response to hypoxia regulation of transcription, DNA-templated positive regulation of cell-cell adhesion embryonic heart tube left/right pattern formation ventricular septum morphogenesis outflow tract morphogenesis negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II spleen development negative regulation of gene expression transcription, DNA-templated response to fluid shear stress response to estrogen positive regulation of transcription, DNA-templated multicellular organism development heart development determination of left/right symmetry positive regulation of gene expression negative regulation of cell migration positive regulation of cell cycle regulation of animal organ formation sex-determination system positive regulation of peroxisome proliferator activated receptor signaling pathway liver development left/right pattern formation negative regulation of transcription from RNA polymerase II promoter in response to hypoxia cell population proliferation negative regulation of transcription, DNA-templated left/right axis specification positive regulation of male gonad development positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10370 17684 Ensembl ENSG00000164442 ENSMUSG00000039910 UniProt Q99967 O35740 RefSeq (mRNA) NM_006079 NM_001168388 NM_001168389 NM_010828 RefSeq (protein) NP_001161860 NP_001161861 NP_006070 NP_034958 Location (UCSC) Chr 6: 139.37 – 139.37 Mb Chr 10: 17.6 – 17.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CITED2 has been shown to interact with EP300,^{[8][9][10][11]} LHX2,^[11] TFAP2A,^[9][10] and WT1.^[12]