CIZ1

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.^[5][6]

CIZ1
Identifiers
Aliases	CIZ1, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1
External IDs	OMIM: 611420; MGI: 1920234; HomoloGene: 8112; GeneCards: CIZ1; OMA:CIZ1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,161,251 bp[1] End 128,204,383 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 32,242,339 bp[2] End 32,270,982 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum left ovary right ovary tibial nerve canal of the cervix body of pancreas skin of leg body of uterus skin of abdomen muscle layer of sigmoid colon Top expressed in genital tubercle neural layer of retina tail of embryo aortic valve yolk sac primary visual cortex ascending aorta ventricular zone muscle of thigh granulocyte More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 25792 68379 Ensembl ENSG00000148337 ENSMUSG00000039205 UniProt Q9ULV3 n/a RefSeq (mRNA) NM_001131015 NM_001131016 NM_001131017 NM_001131018 NM_001257975 NM_001257976 NM_012127 NM_001252534 NM_001252536 NM_001252537 NM_001252538 NM_028412 RefSeq (protein) NP_001124487 NP_001124488 NP_001124489 NP_001124490 NP_001244904 NP_001244905 NP_036259 n/a Location (UCSC) Chr 9: 128.16 – 128.2 Mb Chr 2: 32.24 – 32.27 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.^[6]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.^[7]

Ciz1 mutant mice

Aged (18-mo-old) Ciz1^-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.^[8] Embryonic fibroblasts from Ciz1^-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.^[8]

Interactions

CIZ1 has been shown to interact with P21.^[5]