CKAP2

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.^[5][6]

CKAP2
Identifiers
Aliases	CKAP2, LB1, TMAP, se20-10, cytoskeleton associated protein 2
External IDs	OMIM: 611569; MGI: 1931797; HomoloGene: 10070; GeneCards: CKAP2; OMA:CKAP2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.3 Start 52,455,429 bp[1] End 52,476,628 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 22,658,176 bp[2] End 22,675,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence oocyte secondary oocyte testicle gonad bone marrow trabecular bone monocyte bone marrow cells Top expressed in secondary oocyte zygote ventricular zone primary oocyte medial ganglionic eminence endothelial cell of lymphatic vessel fetal liver hematopoietic progenitor cell otic placode genital tubercle hand More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 26586 80986 Ensembl ENSG00000136108 ENSMUSG00000037725 UniProt Q8WWK9 Q3V1H1 RefSeq (mRNA) NM_001098525 NM_001286686 NM_001286687 NM_018204 NM_001004140 RefSeq (protein) NP_001091995 NP_001273615 NP_001273616 NP_060674 NP_001004140 Location (UCSC) Chr 13: 52.46 – 52.48 Mb Chr 8: 22.66 – 22.68 Mb PubMed search [3] [4]
Wikidata
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Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton-associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils. The CKAP2 gene is in chromosome 13q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia.