CKS2

For the aerodrome using the TC LID, CKS2, see Kennisis Lake/Francis Water Aerodrome.

Cyclin-dependent kinases regulatory subunit 2 is a protein that in humans is encoded by the CKS2 gene.^[5][6][7]

CKS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CKS, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CKS2, CKSHS2, CDC28 protein kinase regulatory subunit 2
External IDs	OMIM: 116901; MGI: 1913447; HomoloGene: 86883; GeneCards: CKS2; OMA:CKS2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.2 Start 89,311,195 bp[1] End 89,316,703 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 51,799,268 bp[2] End 51,804,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone right testis left testis testicle ganglionic eminence sperm oocyte trabecular bone gonad mucosa of transverse colon Top expressed in morula zygote secondary oocyte primary oocyte embryo epiblast ventricular zone embryo yolk sac blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase regulator activity chromatin binding histone binding protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity ubiquitin binding protein binding Cellular component SCF ubiquitin ligase complex cyclin-dependent protein kinase holoenzyme complex Biological process cell cycle meiosis I cell division regulation of mitotic cell cycle positive regulation of cyclin-dependent protein serine/threonine kinase activity cell population proliferation positive regulation of transcription, DNA-templated mitotic cell cycle phase transition regulation of transcription by RNA polymerase II regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1164 66197 Ensembl ENSG00000123975 ENSMUSG00000062248 UniProt P33552 P56390 RefSeq (mRNA) NM_001827 NM_025415 RefSeq (protein) NP_001818 NP_079691 Location (UCSC) Chr 9: 89.31 – 89.32 Mb Chr 13: 51.8 – 51.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.^[7]