CLCA4

Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.^[5] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[6]

CLCA4
Identifiers
Aliases	CLCA4, CaCC, CaCC2, chloride channel accessory 4
External IDs	OMIM: 616857; MGI: 2139744; HomoloGene: 40808; GeneCards: CLCA4; OMA:CLCA4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,547,078 bp[1] End 86,580,754 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 144,658,241 bp[2] End 144,680,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon oral cavity mucosa of pharynx rectum mucosa of transverse colon cervix epithelium mucosa of urinary bladder mucosa of ileum nasal epithelium Top expressed in jejunum Paneth cell left colon ileum duodenum conjunctival fornix lumbar subsegment of spinal cord cornea ciliary body embryo More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity hydrolase activity metallopeptidase activity metal ion binding chloride channel activity metalloendopeptidase activity intracellular calcium activated chloride channel activity Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane apical plasma membrane membrane Biological process ion transmembrane transport chloride transport proteolysis chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22802 99663 Ensembl ENSG00000016602 ENSMUSG00000068547 UniProt Q14CN2 Q6Q473 RefSeq (mRNA) NM_012128 NM_207208 RefSeq (protein) NP_036260 NP_997091 Location (UCSC) Chr 1: 86.55 – 86.58 Mb Chr 3: 144.66 – 144.68 Mb PubMed search [3] [4]
Wikidata
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See also

• Chloride channel