CLDN15

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene.^[5] It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.^[6]

CLDN15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P79
Identifiers
Aliases	CLDN15, claudin 15
External IDs	OMIM: 615778; MGI: 1913103; HomoloGene: 8646; GeneCards: CLDN15; OMA:CLDN15 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 101,232,092 bp[1] End 101,238,820 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,995,470 bp[2] End 137,004,712 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum mucosa of ileum germinal epithelium mucosa of transverse colon granulocyte parietal pleura right lobe of liver left uterine tube spleen Top expressed in duodenum crypt of lieberkuhn of small intestine intestinal villus granulocyte jejunum Paneth cell epithelium of small intestine ileum left colon oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component integral component of membrane cell junction plasma membrane lateral plasma membrane membrane bicellular tight junction Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24146 60363 Ensembl ENSG00000106404 ENSMUSG00000001739 UniProt P56746 Q9Z0S5 RefSeq (mRNA) NM_138429 NM_001185080 NM_014343 NM_021719 RefSeq (protein) NP_001172009 NP_055158 NP_068365 Location (UCSC) Chr 7: 101.23 – 101.24 Mb Chr 5: 137 – 137 Mb PubMed search [3] [4]
Wikidata
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