CLDN17

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.^[5][6] It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.^[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.^[8][9]

CLDN17
Identifiers
Aliases	CLDN17, claudin 17
External IDs	OMIM: 617005; MGI: 2652030; HomoloGene: 8116; GeneCards: CLDN17; OMA:CLDN17 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 30,165,565 bp[1] End 30,166,805 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 88,302,695 bp[2] End 88,303,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle cervix epithelium oral cavity human penis epithelium of esophagus gums vagina body of tongue vulva gingival epithelium Top expressed in esophagus embryo ear surface ectoderm nose pharyngeal arch lip stomach zone of skin visual system More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding chloride channel activity protein binding Cellular component integral component of membrane cell junction plasma membrane membrane bicellular tight junction chloride channel complex Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ion transport chloride transport chloride transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26285 239931 Ensembl ENSG00000156282 ENSMUSG00000055811 UniProt P56750 Q8BXA6 RefSeq (mRNA) NM_012131 NM_181490 RefSeq (protein) NP_036263 NP_852467 Location (UCSC) Chr 21: 30.17 – 30.17 Mb Chr 16: 88.3 – 88.3 Mb PubMed search [3] [4]
Wikidata
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