CLDN18

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.^[5] It belongs to the group of claudins.

CLDN18
Identifiers
Aliases	CLDN18, SFTA5, SFTPJ, claudin 18
External IDs	OMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 137,998,735 bp[1] End 138,033,655 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 99,571,514 bp[2] End 99,599,320 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pylorus lower lobe of lung cardia right lung upper lobe of lung upper lobe of left lung body of stomach gastric mucosa visceral pleura fundus Top expressed in mucous cell of stomach right lung lobe epithelium of stomach pyloric antrum left lung left lung lobe blastocyst duodenum embryo right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component integral component of membrane cell junction plasma membrane membrane bicellular tight junction Biological process negative regulation of protein localization to nucleus TNFSF11-mediated signaling pathway calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules digestive tract development negative regulation of osteoclast development negative regulation of bone resorption response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51208 56492 Ensembl ENSG00000066405 ENSMUSG00000032473 UniProt P56856 P56857 RefSeq (mRNA) NM_016369 NM_001002026 NM_001194921 NM_001194922 NM_001194923 NM_019815 RefSeq (protein) NP_001002026 NP_057453 NP_001181850 NP_001181851 NP_001181852 NP_062789 Location (UCSC) Chr 3: 138 – 138.03 Mb Chr 9: 99.57 – 99.6 Mb PubMed search [3] [4]
Wikidata
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CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .^[6] [supplied by OMIM]^[5]

Clinical significance

Isoform 2 (Claudin 18.2) is abundant in gastric tumors.^[7]

Zolbetuximab targets Claudin 18.2 to help treat gastric cancers.^[8]