CLDN19

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.^[5] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.^[6][7]

CLDN19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3X29
Identifiers
Aliases	CLDN19, HOMG5, claudin 19
External IDs	OMIM: 610036; MGI: 3033992; HomoloGene: 17528; GeneCards: CLDN19; OMA:CLDN19 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 42,733,093 bp[1] End 42,740,254 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 119,112,611 bp[2] End 119,119,635 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion spinal ganglia retinal pigment epithelium renal medulla tibial nerve vena cava epithelium of nasopharynx body of tongue ventral tegmental area trachea Top expressed in sciatic nerve right kidney inner renal medulla outer renal medulla spinal ganglia lip human kidney lens embryo muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity identical protein binding protein binding Cellular component cytoplasm integral component of membrane cell junction plasma membrane basolateral plasma membrane apical junction complex nucleus bicellular tight junction membrane Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules apical junction assembly neuronal action potential propagation response to stimulus visual perception tight junction organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149461 242653 Ensembl ENSG00000164007 ENSMUSG00000066058 UniProt Q8N6F1 Q9ET38 RefSeq (mRNA) NM_148960 NM_001123395 NM_001185117 NM_001038590 NM_153105 RefSeq (protein) NP_001116867 NP_001172046 NP_683763 NP_001033679 NP_694745 Location (UCSC) Chr 1: 42.73 – 42.74 Mb Chr 4: 119.11 – 119.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM]^[5]