CLEC16A

C-type lectin domain family 16, also known as CLEC16A, is a protein that in humans is encoded by the CLEC16A gene.^[5][6][7]

CLEC16A
Identifiers
Aliases	CLEC16A, Gop-1, KIAA0350, C-type lectin domain family 16 member A, C-type lectin domain containing 16A
External IDs	OMIM: 611303; MGI: 1921624; HomoloGene: 71019; GeneCards: CLEC16A; OMA:CLEC16A - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.13 Start 10,944,564 bp[1] End 11,182,186 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 10,363,203 bp[2] End 10,562,742 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sural nerve right hemisphere of cerebellum epithelium of colon apex of heart right frontal lobe Brodmann area 10 anterior pituitary gastrocnemius muscle Top expressed in dentate gyrus of hippocampal formation granule cell muscle of thigh primary visual cortex superior frontal gyrus medial geniculate nucleus cerebellar cortex subiculum inferior colliculi primary motor cortex lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component lysosomal membrane endosome lysosome endosome membrane membrane endolysosome membrane Golgi apparatus cytosol vesicle late endosome integral component of membrane Biological process autophagy positive regulation of autophagosome maturation negative regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of mitophagy cellular response to starvation negative regulation of autophagosome maturation positive regulation of TORC1 signaling negative regulation of macroautophagy by TORC1 signaling endosome to lysosome transport endosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23274 74374 Ensembl ENSG00000038532 ENSMUSG00000068663 UniProt Q2KHT3 Q80U30 RefSeq (mRNA) NM_001243403 NM_015226 NM_001204229 NM_177562 RefSeq (protein) NP_001230332 NP_056041 NP_001191158 NP_808230 Location (UCSC) Chr 16: 10.94 – 11.18 Mb Chr 16: 10.36 – 10.56 Mb PubMed search [3] [4]
Wikidata
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Function

Little is known regarding the function of the CLEC16A protein, however it is shown to be highly expressed on B-lymphocytes, natural killer (NK) and dendritic cells. Despite its name CLEC16A may not function as a lectin because its C-type lectin domain is only 20 amino-acids long.^[8]

Clinical significance

Polymorphisms in the CLEC16A gene are associated with an increased risk of multiple sclerosis^[9] as well as type I diabetes.^[8]