CLEC2B

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.^[3][4]

CLEC2B
Identifiers
Aliases	CLEC2B, AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B
External IDs	OMIM: 603242; HomoloGene: 68443; GeneCards: CLEC2B; OMA:CLEC2B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 9,852,369 bp[1] End 9,869,386 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip periodontal fiber glutes vena cava pericardium mononuclear cell human penis monocyte vulva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding identical protein binding Cellular component plasma membrane integral component of plasma membrane integral component of membrane membrane Biological process regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9976 n/a Ensembl ENSG00000110852 n/a UniProt Q92478 n/a RefSeq (mRNA) NM_005127 n/a RefSeq (protein) NP_005118 n/a Location (UCSC) Chr 12: 9.85 – 9.87 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[4]