CLIC6

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.^[5][6]

CLIC6
Identifiers
Aliases	CLIC6, CLIC1L, chloride intracellular channel 6
External IDs	OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.12 Start 34,668,994 bp[1] End 34,718,227 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 92,282,624 bp[2] End 92,338,131 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium bronchial epithelial cell nasal epithelium caput epididymis palpebral conjunctiva epithelium of nasopharynx mucosa of paranasal sinus pancreatic epithelial cell olfactory zone of nasal mucosa pancreatic ductal cell Top expressed in Epithelium of choroid plexus epithelium of stomach retinal pigment epithelium olfactory epithelium ciliary body migratory enteric neural crest cell epithelium of small intestine yolk sac left colon efferent ductule More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity glutathione transferase activity chloride channel activity D2 dopamine receptor binding D3 dopamine receptor binding D4 dopamine receptor binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane chloride channel complex nucleus cytoplasm Biological process regulation of ion transmembrane transport chloride transport ion transport glutathione metabolic process chloride transmembrane transport transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54102 209195 Ensembl ENSG00000159212 ENSMUSG00000022949 UniProt Q96NY7 Q8BHB9 RefSeq (mRNA) NM_053277 NM_001317009 NM_172469 RefSeq (protein) NP_001303938 NP_444507 NP_766057 Location (UCSC) Chr 21: 34.67 – 34.72 Mb Chr 16: 92.28 – 92.34 Mb PubMed search [3] [4]
Wikidata
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The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.^[6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3.^[7]

Function

CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. ^[8]

See also

• Chloride channel