CLIP1

CAP-Gly domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.^[5]

CLIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CP5, 2CP6, 2E3H, 2E3I, 2E4H, 2HQH, 2QK0, 3E2U, 3RDV
Identifiers
Aliases	CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain containing linker protein 1
External IDs	OMIM: 179838; MGI: 1928401; HomoloGene: 74455; GeneCards: CLIP1; OMA:CLIP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,271,432 bp[1] End 122,422,669 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 123,577,795 bp[2] End 123,684,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii buccal mucosa cell Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii gastrocnemius muscle muscle of thigh tendon of biceps brachii tail of epididymis gingival epithelium amniotic fluid Top expressed in vastus lateralis muscle muscle of thigh triceps brachii muscle temporal muscle medial head of gastrocnemius muscle sternocleidomastoid muscle digastric muscle tibialis anterior muscle soleus muscle lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity microtubule binding microtubule plus-end binding metal ion binding tubulin binding protein binding zinc ion binding identical protein binding Cellular component cytosol endosome centrosome cell projection membrane microtubule cytoskeleton ruffle microtubule plus-end macropinosome cytoplasmic microtubule microtubule cytoskeleton intermediate filament cytoplasmic vesicle membrane cytoplasmic vesicle kinetochore nuclear envelope cytoplasm Biological process microtubule bundle formation positive regulation of microtubule polymerization protein transport into plasma membrane raft mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6249 56430 Ensembl ENSG00000130779 ENSMUSG00000049550 UniProt P30622 Q922J3 RefSeq (mRNA) NM_001247997 NM_002956 NM_198240 NM_001389291 NM_001291229 NM_019765 NM_001347468 NM_001359220 NM_001359221 NM_001359222 NM_001359223 NM_001359224 RefSeq (protein) NP_001234926 NP_002947 NP_937883 NP_001278158 NP_001334397 NP_062739 NP_001346149 NP_001346150 NP_001346151 NP_001346152 NP_001346153 Location (UCSC) Chr 12: 122.27 – 122.42 Mb Chr 5: 123.58 – 123.68 Mb PubMed search [3] [4]
Wikidata
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Interactions

CLIP1 has been shown to interact with IQGAP1,^[6] Mammalian target of rapamycin^[7] and PAFAH1B1.^[8]