CLIP2

CAP-Gly domain-containing linker protein 2 is a protein that in humans is encoded by the CLIP2 gene.^[5][6][7]

CLIP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CP2, 2CP3
Identifiers
Aliases	CLIP2, CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4, CAP-Gly domain containing linker protein 2
External IDs	OMIM: 603432; MGI: 1313136; HomoloGene: 20718; GeneCards: CLIP2; OMA:CLIP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 74,289,407 bp[1] End 74,405,935 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 74.63 cM Start 134,518,237 bp[2] End 134,581,288 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment ganglionic eminence dorsal motor nucleus of vagus nerve prefrontal cortex inferior olivary nucleus optic nerve right frontal lobe amygdala Brodmann area 10 postcentral gyrus Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex ventricular zone supraoptic nucleus molar granulocyte cerebellar cortex neural layer of retina genital tubercle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 7461 269713 Ensembl ENSG00000106665 ENSMUSG00000063146 UniProt Q9UDT6 Q9Z0H8 RefSeq (mRNA) NM_032421 NM_003388 NM_001039162 NM_009990 RefSeq (protein) NP_003379 NP_115797 NP_001034251 NP_034120 Location (UCSC) Chr 7: 74.29 – 74.41 Mb Chr 5: 134.52 – 134.58 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.^[7]