CLK1

This article is about the kinase protein enzyme. For other uses, see CLK-1 (disambiguation).

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.^[5][6]

CLK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z57, 2VAG, 5J1V, 5J1W
Identifiers
Aliases	CLK1, CLK, CLK/STY, STY, CDC like kinase 1
External IDs	OMIM: 601951; MGI: 107403; HomoloGene: 101535; GeneCards: CLK1; OMA:CLK1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 200,853,009 bp[1] End 200,864,691 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.3|1 29.09 cM Start 58,449,348 bp[2] End 58,463,225 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right uterine tube right ovary left ovary tibial nerve anterior pituitary C1 segment left lobe of thyroid gland canal of the cervix gastric mucosa Top expressed in granulocyte neural layer of retina pineal gland spleen lymph node left lung lobe superior cervical ganglion blood tunica media of zone of aorta skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine/tyrosine kinase activity protein serine/threonine kinase activity protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity Cellular component cytoplasm nucleus Biological process protein autophosphorylation peptidyl-tyrosine phosphorylation regulation of RNA splicing protein phosphorylation cell population proliferation peptidyl-threonine phosphorylation peptidyl-serine phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1195 12747 Ensembl ENSG00000013441 ENSMUSG00000026034 UniProt P49759 P22518 RefSeq (mRNA) NM_001024646 NM_001162407 NM_004071 NM_001042634 NM_009905 RefSeq (protein) NP_001155879 NP_004062 NP_001036099 Location (UCSC) Chr 2: 200.85 – 200.86 Mb Chr 1: 58.45 – 58.46 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.^[6]

Interactions

CLK1 has been shown to interact with ASF/SF2.^[7][8]