CLK2

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.^[5][6][7]

CLK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NR9
Identifiers
Aliases	CLK2, CDC like kinase 2
External IDs	OMIM: 602989; MGI: 1098669; HomoloGene: 33303; GeneCards: CLK2; OMA:CLK2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,262,868 bp[1] End 155,278,491 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 89,072,102 bp[2] End 89,084,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland pituitary gland spleen right adrenal cortex left lobe of thyroid gland anterior pituitary right ovary left ovary left adrenal cortex Top expressed in genital tubercle tail of embryo zygote secondary oocyte neural layer of retina condyle fossa epiblast ventricular zone granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinase activity protein serine/threonine kinase activity protein kinase activity protein serine/threonine/tyrosine kinase activity ATP binding nucleotide binding protein tyrosine kinase activity transferase activity identical protein binding Cellular component nucleoplasm nucleus nuclear speck nuclear body Biological process negative regulation of gluconeogenesis regulation of RNA splicing phosphorylation protein phosphorylation protein autophosphorylation response to organic substance response to ionizing radiation peptidyl-tyrosine phosphorylation response to retinoic acid Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1196 12748 Ensembl ENSG00000261893 ENSG00000176444 ENSMUSG00000068917 UniProt P49760 O35491 RefSeq (mRNA) NM_001291 NM_001294338 NM_001294339 NM_003993 NM_001363704 NM_001163432 NM_007712 RefSeq (protein) NP_001281267 NP_001281268 NP_003984 NP_001350633 NP_001156904 NP_031738 Location (UCSC) Chr 1: 155.26 – 155.28 Mb Chr 3: 89.07 – 89.08 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.^[7]