CLPTM1L

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene.^[5][6] CRR9p is associated with cisplatin-induced apoptosis.^[6] CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL.^[7] Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.^[8]

CLPTM1L
Identifiers
Aliases	CLPTM1L, CRR9, CLPTM1-like, CLPTM1 like
External IDs	OMIM: 612585; MGI: 2442892; HomoloGene: 12767; GeneCards: CLPTM1L; OMA:CLPTM1L - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.33 Start 1,317,752 bp[1] End 1,345,099 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 73,752,125 bp[2] End 73,768,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum right lobe of thyroid gland body of pancreas left lobe of thyroid gland oocyte upper lobe of left lung gonad secondary oocyte right lobe of liver body of stomach Top expressed in lacrimal gland salivary gland submandibular gland seminal vesicula parotid gland calvaria vestibular membrane of cochlear duct stroma of bone marrow crypt of lieberkuhn of small intestine medullary collecting duct More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 81037 218335 Ensembl ENSG00000049656 ENSG00000274811 ENSMUSG00000021610 UniProt Q96KA5 Q8BXA5 RefSeq (mRNA) NM_030782 NM_146047 RefSeq (protein) NP_110409 NP_666159 Location (UCSC) Chr 5: 1.32 – 1.35 Mb Chr 13: 73.75 – 73.77 Mb PubMed search [3] [4]
Wikidata
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See also

• Cleft lip and palate transmembrane protein 1