CLTC

For the Chinese vehicle testing standard, see China Light-Duty Vehicle Test Cycle. For the religious organization in Papua New Guinea, see Christian Leaders' Training College.

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.^[5][6]

CLTC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZG, 4G55
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
External IDs	OMIM: 118955; MGI: 2388633; HomoloGene: 3572; GeneCards: CLTC; OMA:CLTC - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.1 Start 59,619,689 bp[1] End 59,696,956 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 86,585,177 bp[2] End 86,648,391 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pons lateral nuclear group of thalamus Brodmann area 46 middle temporal gyrus mucosa of sigmoid colon orbitofrontal cortex postcentral gyrus corpus epididymis trabecular bone pars compacta Top expressed in stroma of bone marrow habenula pontine nuclei medial geniculate nucleus medial dorsal nucleus medial vestibular nucleus dorsomedial hypothalamic nucleus lateral geniculate nucleus deep cerebellar nuclei ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding double-stranded RNA binding protein kinase binding structural molecule activity RNA binding clathrin light chain binding disordered domain specific binding low-density lipoprotein particle receptor binding ubiquitin-specific protease binding Cellular component extracellular vesicle cytosol clathrin-coated endocytic vesicle membrane clathrin coat of coated pit trans-Golgi network membrane clathrin coat of trans-Golgi network vesicle focal adhesion melanosome plasma membrane endolysosome membrane clathrin-coated pit extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle clathrin-coated vesicle extracellular matrix membrane mitotic spindle microtubule cytoplasm lysosome endosome spindle cytoskeleton clathrin coat clathrin complex protein-containing complex intracellular membrane-bounded organelle clathrin-coated endocytic vesicle mitotic spindle intracellular anatomical structure Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II transferrin transport receptor internalization negative regulation of protein localization to plasma membrane retrograde transport, endosome to Golgi osteoblast differentiation vesicle-mediated transport negative regulation of hyaluronan biosynthetic process intracellular protein transport Wnt signaling pathway, planar cell polarity pathway regulation of mitotic spindle organization autophagy microtubule-based movement cell cycle cell division membrane organization mitotic cell cycle receptor-mediated endocytosis low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance clathrin coat assembly clathrin-dependent endocytosis amyloid-beta clearance by transcytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1213 67300 Ensembl ENSG00000141367 ENSMUSG00000047126 UniProt Q00610 Q68FD5 RefSeq (mRNA) NM_001288653 NM_004859 NM_001003908 NM_001356393 RefSeq (protein) NP_001275582 NP_004850 NP_001003908 NP_001343322 Location (UCSC) Chr 17: 59.62 – 59.7 Mb Chr 11: 86.59 – 86.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.^[7]

Interactions

CLTC has been shown to interact with PICALM^[8] and HGS.^[9]

See also

• Clathrin