CNOT2

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene.^[5][6] It is a subunit of the CCR4-Not deadenylase complex.

CNOT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0D, 4C0F, 5FU6, 5FU7
Identifiers
Aliases	CNOT2, CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS
External IDs	OMIM: 604909; MGI: 1919318; HomoloGene: 40953; GeneCards: CNOT2; OMA:CNOT2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 70,243,002 bp[1] End 70,354,993 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 116,321,066 bp[2] End 116,417,416 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon nipple epithelium of nasopharynx human penis epithelium of colon ganglionic eminence skin of abdomen cerebellar cortex Top expressed in genital tubercle ciliary body internal carotid artery external carotid artery medullary collecting duct iris tail of embryo primitive streak retinal pigment epithelium cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity transcription coregulator activity protein binding Cellular component cytoplasm membrane CCR4-NOT complex P-body CCR4-NOT core complex nucleus cytosol plasma membrane Biological process nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II transcription, DNA-templated multicellular organism development positive regulation of cytoplasmic mRNA processing body assembly trophectodermal cell differentiation gene silencing negative regulation of intracellular estrogen receptor signaling pathway regulation of translation nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4848 72068 Ensembl ENSG00000111596 ENSMUSG00000020166 UniProt Q9NZN8 Q8C5L3 RefSeq (mRNA) NM_001199302 NM_001199303 NM_014515 NM_001037846 NM_001037847 NM_001037848 NM_028082 NM_001359247 NM_001359248 NM_001359249 NM_001359250 NM_001359251 NM_001359252 NM_001359253 NM_001359563 RefSeq (protein) NP_001186231 NP_001186232 NP_055330 NP_001032935 NP_001032936 NP_001032937 NP_082358 NP_001346176 NP_001346177 NP_001346178 NP_001346179 NP_001346180 NP_001346181 NP_001346182 NP_001346492 Location (UCSC) Chr 12: 70.24 – 70.35 Mb Chr 10: 116.32 – 116.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse