CNOT4

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.^[5]

CNOT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E4U, 1UR6
Identifiers
Aliases	CNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDs	OMIM: 604911; MGI: 1859026; HomoloGene: 40870; GeneCards: CNOT4; OMA:CNOT4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 135,361,795 bp[1] End 135,510,127 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 34,999,000 bp[2] End 35,110,659 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon testicle gastrocnemius muscle parietal pleura corpus callosum internal globus pallidus sural nerve endothelial cell muscle of thigh Top expressed in genital tubercle Rostral migratory stream tail of embryo zygote saccule primary oocyte secondary oocyte otic placode fossa otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding nucleic acid binding metal ion binding transferase activity RNA binding Cellular component cytosol cytoplasm CCR4-NOT complex nucleus Biological process protein ubiquitination nuclear-transcribed mRNA poly(A) tail shortening protein autoubiquitination DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ubiquitin-dependent protein catabolic process regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4850 53621 Ensembl ENSG00000080802 ENSMUSG00000038784 UniProt O95628 Q8BT14 RefSeq (mRNA) NM_001008225 NM_001190847 NM_001190848 NM_001190849 NM_001190850 NM_013316 NM_001393370 NM_001393371 NM_001393372 NM_001393373 NM_001393374 NM_001393375 NM_001164411 NM_001164412 NM_001164413 NM_001164414 NM_016877 RefSeq (protein) NP_001008226 NP_001177776 NP_001177777 NP_001177778 NP_001177779 NP_037448 NP_001157883 NP_001157884 NP_001157885 NP_001157886 NP_058573 Location (UCSC) Chr 7: 135.36 – 135.51 Mb Chr 6: 35 – 35.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.^[6]