CNOT8

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene.^[5][6][7] It is a subunit of the CCR4-Not deadenylase complex.

CNOT8
Identifiers
Aliases	CNOT8, CAF1, CALIF, Caf1b, POP2, hCAF1, CCR4-NOT transcription complex subunit 8
External IDs	OMIM: 603731; MGI: 1916375; HomoloGene: 48304; GeneCards: CNOT8; OMA:CNOT8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 154,857,553 bp[1] End 154,876,792 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 57,994,979 bp[2] End 58,009,420 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte sperm right lung ganglionic eminence Achilles tendon granulocyte rectum upper lobe of left lung ventricular zone Top expressed in secondary oocyte neural layer of retina thymus zygote medial ganglionic eminence granulocyte ventricular zone primary oocyte neural tube morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity 3'-5'-exoribonuclease activity DNA-binding transcription factor activity metal ion binding protein binding RNA binding nucleic acid binding nuclease activity exonuclease activity hydrolase activity Cellular component cytoplasm cytosol CCR4-NOT complex intracellular anatomical structure nucleus P-body CCR4-NOT core complex Biological process regulation of transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis positive regulation of mRNA catabolic process transcription, DNA-templated gene silencing by miRNA positive regulation of cell population proliferation exonucleolytic catabolism of deadenylated mRNA gene silencing regulation of translation negative regulation of cell population proliferation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9337 69125 Ensembl ENSG00000155508 ENSMUSG00000020515 UniProt Q9UFF9 Q9D8X5 RefSeq (mRNA) NM_001301073 NM_001301074 NM_001301075 NM_001301077 NM_001301080 NM_001301082 NM_001301083 NM_001301086 NM_004779 NM_026949 NM_001356477 NM_001363084 NM_001363085 NM_001363086 RefSeq (protein) NP_001288002 NP_001288003 NP_001288004 NP_001288006 NP_001288009 NP_001288011 NP_001288012 NP_001288015 NP_004770 NP_081225 NP_001343406 NP_001350013 NP_001350014 NP_001350015 Location (UCSC) Chr 5: 154.86 – 154.88 Mb Chr 11: 57.99 – 58.01 Mb PubMed search [3] [4]
Wikidata
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Interactions

CNOT8 has been shown to interact with BTG2,^[8] BTG1,^[8][9] CNOT1^[6][10] and CNOT3.^[6]