CNOT9

CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene. ^[5]

CNOT9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FV2, 4CRU, 4CRV, 4CT6, 4CT7
Identifiers
Aliases	CNOT9, CT129, RCD-1, RCD1, CAF40, RQCD1, CCR4-NOT transcription complex subunit 9
External IDs	OMIM: 612054; MGI: 1928902; HomoloGene: 3973; GeneCards: CNOT9; OMA:CNOT9 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,568,580 bp[1] End 218,597,080 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 74,545,217 bp[2] End 74,570,001 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium epithelium of nasopharynx ganglionic eminence right uterine tube lymph node stromal cell of endometrium gastric mucosa Achilles tendon anterior pituitary rectum Top expressed in tail of embryo genital tubercle yolk sac epiblast somite ventricular zone maxillary prominence zygote mandibular prominence fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity protein domain specific binding protein binding epidermal growth factor receptor binding kinase binding Cellular component cytoplasm cytosol membrane CCR4-NOT complex P-body CCR4-NOT core complex nucleus protein-containing complex Biological process nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation regulation of transcription, DNA-templated mRNA catabolic process cytokine-mediated signaling pathway sex differentiation transcription, DNA-templated gene silencing negative regulation of intracellular estrogen receptor signaling pathway regulation of translation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of peptidyl-serine phosphorylation positive regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9125 58184 Ensembl ENSG00000144580 ENSMUSG00000026174 UniProt Q92600 Q9JKY0 RefSeq (mRNA) NM_001271634 NM_001271635 NM_005444 NM_021383 RefSeq (protein) NP_001258563 NP_001258564 NP_005435 NP_067358 Location (UCSC) Chr 2: 218.57 – 218.6 Mb Chr 1: 74.55 – 74.57 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].