Contactin 1

Contactin 1 (CNTN1) is a protein which in humans is encoded by the CNTN1 gene.^[5][6]

CNTN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE2, 3S97
Identifiers
Aliases	CNTN1, F3, GP135, MYPCN, contactin 1
External IDs	OMIM: 600016; MGI: 105980; HomoloGene: 7274; GeneCards: CNTN1; OMA:CNTN1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q12 Start 40,692,439 bp[1] End 41,072,415 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E3|15 46.39 cM Start 91,949,046 bp[2] End 92,239,848 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell superior frontal gyrus postcentral gyrus entorhinal cortex prefrontal cortex cerebellar cortex primary visual cortex amygdala cerebellar hemisphere Top expressed in lateral geniculate nucleus ventromedial nucleus lateral septal nucleus medial geniculate nucleus mammillary body ventral tegmental area medial dorsal nucleus lateral hypothalamus anterior amygdaloid area globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding protein binding Cellular component myelin sheath anchored component of membrane membrane raft plasma membrane extracellular exosome membrane anchored component of postsynaptic membrane anchored component of presynaptic membrane Biological process positive regulation of peptidyl-tyrosine phosphorylation nervous system development cell adhesion positive regulation of gene expression neuron projection development positive regulation of sodium ion transport cerebellum development positive regulation of neuron projection development Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1272 12805 Ensembl ENSG00000018236 ENSMUSG00000055022 UniProt Q12860 P12960 RefSeq (mRNA) NM_001256063 NM_001256064 NM_001843 NM_175038 NM_001159647 NM_001159648 NM_007727 NM_001358051 RefSeq (protein) NP_001242992 NP_001242993 NP_001834 NP_778203 NP_001153119 NP_001153120 NP_031753 NP_001344980 Location (UCSC) Chr 12: 40.69 – 41.07 Mb Chr 15: 91.95 – 92.24 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[6]

Interactions

CNTN1 has been shown to interact with PTPRB.^[7][8]