COMMD1

COMM domain-containing protein 1 is a protein that is encoded by the COMMD1 gene in humans. It was originally regarded as Murr1 before being differentiated and renamed by Dr. Ezra Burstein's Lab^[5][6][7]

COMMD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H2M
Identifiers
Aliases	COMMD1, C2orf5, MURR1, copper metabolism domain containing 1
External IDs	OMIM: 607238; MGI: 109474; HomoloGene: 17604; GeneCards: COMMD1; OMA:COMMD1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p15 Start 61,888,724 bp[1] End 62,147,247 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.2|11 14.22 cM Start 22,846,136 bp[2] End 22,932,382 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle tibialis anterior muscle cardiac muscle tissue of right atrium right ventricle deltoid muscle Skeletal muscle tissue of biceps brachii right auricle of heart vena cava skin of arm mucosa of ileum Top expressed in embryo embryo spermatocyte right kidney ventricular zone external carotid artery intercostal muscle epiblast medullary collecting duct internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity phosphatidylinositol-3,5-bisphosphate binding metal ion binding phosphatidylinositol-3,4-bisphosphate binding phosphatidic acid binding protein binding identical protein binding phosphatidylinositol-4,5-bisphosphate binding copper ion binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding Cellular component cytoplasm recycling endosome endosome membrane Cul2-RING ubiquitin ligase complex early endosome endosome membrane cytoplasmic vesicle nucleus nucleoplasm cytosol Biological process negative regulation of sodium ion transmembrane transport regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein localization to cell surface plasma membrane to endosome transport regulation of proteasomal ubiquitin-dependent protein catabolic process protein transport negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination Golgi to plasma membrane transport post-translational protein modification copper ion homeostasis protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150684 17846 Ensembl ENSG00000173163 ENSMUSG00000051355 UniProt Q8N668 Q8K4M5 RefSeq (mRNA) NM_152516 NM_001321781 NM_001321782 NM_001371765 NM_144514 NM_001361661 RefSeq (protein) NP_001308710 NP_001308711 NP_689729 NP_001358694 NP_653097 NP_001348590 Location (UCSC) Chr 2: 61.89 – 62.15 Mb Chr 11: 22.85 – 22.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse