COPS2

COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene.^[5][6][7] It encodes a subunit of the COP9 signalosome.

COPS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	COPS2, ALIEN, CSN2, SGN2, TRIP15, COP9 signalosome subunit 2
External IDs	OMIM: 604508; MGI: 1330276; HomoloGene: 134283; GeneCards: COPS2; OMA:COPS2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1 Start 49,106,068 bp[1] End 49,155,661 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 61.76 cM Start 125,672,224 bp[2] End 125,701,059 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue thoracic diaphragm Achilles tendon parietal pleura gingival epithelium tail of epididymis glutes amniotic fluid corpus epididymis germinal epithelium Top expressed in otic placode saccule tail of embryo genital tubercle otic vesicle mandibular prominence maxillary prominence abdominal wall cumulus cell somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity transcription corepressor activity Cellular component nucleoplasm nucleus COP9 signalosome cytoplasm cytosol Biological process negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II nucleotide-excision repair, DNA damage recognition neuron differentiation cell population proliferation signal transduction negative regulation of nucleic acid-templated transcription skeletal muscle cell differentiation transcription-coupled nucleotide-excision repair neurogenesis negative regulation of transcription, DNA-templated protein deneddylation post-translational protein modification protein phosphorylation inner cell mass cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9318 12848 Ensembl ENSG00000166200 ENSMUSG00000027206 UniProt P61201 P61202 RefSeq (mRNA) NM_004236 NM_001143887 NM_001285507 NM_001285512 NM_001285513 NM_009939 RefSeq (protein) NP_001137359 NP_004227 NP_001272436 NP_001272441 NP_001272442 NP_034069 Location (UCSC) Chr 15: 49.11 – 49.16 Mb Chr 2: 125.67 – 125.7 Mb PubMed search [3] [4]
Wikidata
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Interactions

COPS2 has been shown to interact with:

• DAX1,^[8]
• IRF8,^[9]
• NIF3L1,^[10] and
• THRA.^[11]