COPS8

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.^[5][6][7]

COPS8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	COPS8, COP9, CSN8, SGN8, COP9 signalosome subunit 8
External IDs	OMIM: 616011; MGI: 1915363; HomoloGene: 4882; GeneCards: COPS8; OMA:COPS8 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,085,882 bp[1] End 237,100,474 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 90,530,703 bp[2] End 90,541,063 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell lateral nuclear group of thalamus Brodmann area 23 middle temporal gyrus pars reticulata pars compacta pons Skeletal muscle tissue of biceps brachii external globus pallidus Top expressed in spermatocyte yolk sac facial motor nucleus ventricular zone muscle of thigh primary oocyte primitive streak neural tube secondary oocyte dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component perinuclear region of cytoplasm extracellular exosome nucleus nucleoplasm cytoplasm cytosol COP9 signalosome Biological process transcription-coupled nucleotide-excision repair activation of NF-kappaB-inducing kinase activity nucleotide-excision repair, DNA damage recognition negative regulation of cell population proliferation COP9 signalosome assembly protein deneddylation post-translational protein modification protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10920 108679 Ensembl ENSG00000198612 ENSMUSG00000034432 UniProt Q99627 Q8VBV7 RefSeq (mRNA) NM_198189 NM_006710 NM_133805 RefSeq (protein) NP_006701 NP_937832 NP_598566 Location (UCSC) Chr 2: 237.09 – 237.1 Mb Chr 1: 90.53 – 90.54 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[7]