COTL1

Coactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.^[5][6][7][8]

COTL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T2L, 1T3X, 1T3Y, 1TMW, 1VFQ, 1WNJ
Identifiers
Aliases	COTL1, CLP, coactosin like F-actin binding protein 1
External IDs	OMIM: 606748; MGI: 1919292; HomoloGene: 10898; GeneCards: COTL1; OMA:COTL1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 84,565,596 bp[1] End 84,618,078 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 120,535,961 bp[2] End 120,567,283 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood spleen appendix lymph node retinal pigment epithelium ganglionic eminence bone marrow gallbladder Top expressed in granulocyte mesenteric lymph nodes epithelium of stomach migratory enteric neural crest cell epithelium of lens motor neuron yolk sac mucous cell of stomach fossa conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding actin binding Cellular component cytoplasm extracellular exosome cytoskeleton intracellular anatomical structure nucleus extracellular region secretory granule lumen ficolin-1-rich granule lumen Biological process defense response to fungus neutrophil degranulation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23406 72042 Ensembl ENSG00000103187 ENSMUSG00000031827 UniProt Q14019 Q9CQI6 RefSeq (mRNA) NM_021149 NM_028071 RefSeq (protein) NP_066972 NP_082347 Location (UCSC) Chr 16: 84.57 – 84.62 Mb Chr 8: 120.54 – 120.57 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes 5-lipoxygenase (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.^[8]

Interactions

COTL1 has been shown to interact with ALOX5.^[9] ALOX5 is the first committed enzyme in the metabolism of arachidonic acid to an array of biologically important cell signaling agents: a) the pro-inflammatory mediator, leukotriene B4 (LTB4); b) the airways constrictors, LTC4, LTD4, and LTE4; c) the 5-hydroxyeicosatetraenoic acid family of pro-inflammatory and pro-allergic reactions mediators, 5-HETE and 5-oxo-eicosatetraenoic acid. ALOX5 also contributes to the metabolism of arachidonic acid and other polyunsaturated fatty acids to agents which act block inflammation and allergic reactions, the specialized pro-resolving mediators of the lipoxin and resolvin subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a chaperone or scaffold, to avert the enzyme's inactivation and thereby to promote its metabolic activity.^[10]