CPA5

Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene.^[5][6]

CPA5
Identifiers
Aliases	CPA5, carboxypeptidase A5
External IDs	OMIM: 609561; MGI: 1921899; HomoloGene: 62246; GeneCards: CPA5; OMA:CPA5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 130,344,816 bp[1] End 130,368,730 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 30,611,009 bp[2] End 30,631,744 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis sperm gonad lymph node body of pancreas pituitary gland anterior pituitary spleen Top expressed in spermatid seminiferous tubule spermatocyte embryo embryo morula yolk sac genital tubercle islet of Langerhans trachea More reference expression data BioGPS n/a
Gene ontology Molecular function carboxypeptidase activity zinc ion binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity Cellular component extracellular region extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93979 74649 Ensembl ENSG00000158525 ENSMUSG00000029788 UniProt Q8WXQ8 Q8R4H4 RefSeq (mRNA) NM_001127441 NM_001127442 NM_080385 NM_001318223 NM_144537 RefSeq (protein) NP_001120913 NP_001120914 NP_001305152 NP_525124 NP_653120 Location (UCSC) Chr 7: 130.34 – 130.37 Mb Chr 6: 30.61 – 30.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM]^[6]