CPNE6

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.^[5][6]

CPNE6
Identifiers
Aliases	CPNE6, copine 6
External IDs	OMIM: 605688; MGI: 1334445; HomoloGene: 81815; GeneCards: CPNE6; OMA:CPNE6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 24,070,837 bp[1] End 24,078,100 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,747,902 bp[2] End 55,754,888 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in temporal lobe amygdala right hemisphere of cerebellum hippocampus proper superior frontal gyrus right frontal lobe nucleus accumbens anterior cingulate cortex prefrontal cortex putamen Top expressed in CA3 field subiculum dentate gyrus dentate gyrus of hippocampal formation granule cell entorhinal cortex perirhinal cortex hippocampus proper anterior amygdaloid area Region I of hippocampus proper facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transporter activity phosphatidylserine binding protein binding calcium-dependent phospholipid binding Cellular component cytoplasm endosome perikaryon cell projection membrane clathrin-coated endocytic vesicle plasma membrane axon dendrite extracellular exosome cytoplasmic vesicle clathrin-coated vesicle Biological process cellular response to calcium ion cell differentiation lipid metabolism nervous system development glycerophospholipid biosynthetic process positive regulation of dendrite extension vesicle-mediated transport chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9362 12891 Ensembl ENSG00000100884 ENSMUSG00000022212 UniProt O95741 Q9Z140 RefSeq (mRNA) NM_001280558 NM_006032 NM_001136057 NM_001146183 NM_009947 NM_001360193 RefSeq (protein) NP_001267487 NP_006023 NP_001129529 NP_001139655 NP_034077 NP_001347122 Location (UCSC) Chr 14: 24.07 – 24.08 Mb Chr 14: 55.75 – 55.75 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.^[6]