CRADD

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.^[5][6][7]

CRADD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2O71, 2OF5, 3CRD
Identifiers
Aliases	CRADD, MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
External IDs	OMIM: 603454; MGI: 1336168; HomoloGene: 2821; GeneCards: CRADD; OMA:CRADD - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 93,677,375 bp[1] End 93,894,840 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 49.26 cM Start 95,010,608 bp[2] End 95,159,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left ventricle right lobe of liver apex of heart gonad islet of Langerhans right auricle of heart right testis left testis left adrenal gland Top expressed in granulocyte genital tubercle muscle of thigh right kidney proximal tubule tail of embryo Ileal epithelium cardiac muscle tissue of left ventricle medial ganglionic eminence embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein-macromolecule adaptor activity protein binding protease binding death domain binding Cellular component cytoplasm nucleus cytosol Biological process cellular response to mechanical stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors signal transduction apoptotic process regulation of apoptotic process positive regulation of apoptotic process apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8738 12905 Ensembl ENSG00000169372 ENSMUSG00000045867 UniProt P78560 Q8IY43 O88843 RefSeq (mRNA) NM_003805 NM_001320099 NM_001320100 NM_001320101 NM_001330126 NM_009950 NM_001330138 NM_001330141 NM_001330175 RefSeq (protein) NP_001307028 NP_001307029 NP_001307030 NP_001317055 NP_003796 NP_001307028.1 NP_001317067 NP_001317070 NP_001317104 NP_034080 Location (UCSC) Chr 12: 93.68 – 93.89 Mb Chr 10: 95.01 – 95.16 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.^[7]

Interactions

CRADD has been shown to interact with RIPK1^[5][6] and Caspase 2.^[5][8][9]