CRB3

Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.^[5]

CRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5I7Z
Identifiers
Aliases	CRB3, crumbs 3, cell polarity complex component, crumbs cell polarity complex component 3
External IDs	OMIM: 609737; MGI: 2670904; HomoloGene: 138188; GeneCards: CRB3; OMA:CRB3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 6,463,777 bp[1] End 6,467,221 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 57,366,105 bp[2] End 57,372,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx mucosa of transverse colon vena cava nasal epithelium skin of arm body of pancreas parotid gland body of tongue pylorus skin of leg Top expressed in yolk sac secondary oocyte zygote duodenum right kidney stomach morula morula pyloric antrum mucous cell of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding protein binding protein domain specific binding Cellular component integral component of membrane cell junction plasma membrane apical part of cell extracellular exosome apical plasma membrane membrane bicellular tight junction protein-containing complex Biological process protein localization to plasma membrane bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92359 224912 Ensembl ENSG00000130545 ENSMUSG00000044279 UniProt Q9BUF7 Q8QZT4 RefSeq (mRNA) NM_139161 NM_174881 NM_174882 NM_177638 NM_001347408 NM_001359813 NM_001359814 RefSeq (protein) NP_631900 NP_777377 NP_777378 NP_001334337 NP_808306 NP_001346742 NP_001346743 Location (UCSC) Chr 19: 6.46 – 6.47 Mb Chr 17: 57.37 – 57.37 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]