CREB5

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.^[5][6][7]

CREB5
Identifiers
Aliases	CREB5, CRE-BPA, CREB-5, cAMP responsive element binding protein 5, CREBPA
External IDs	OMIM: 618262; MGI: 2443973; HomoloGene: 18215; GeneCards: CREB5; OMA:CREB5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.1-p14.3 Start 28,299,321 bp[1] End 28,825,894 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.9 cM Start 53,264,255 bp[2] End 53,677,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint ventricular zone blood corpus callosum tendon of biceps brachii monocyte inferior ganglion of vagus nerve synovial membrane internal globus pallidus cartilage tissue Top expressed in hand ascending aorta aortic valve foot lumbar subsegment of spinal cord hair follicle ventricular zone genital tubercle external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component extracellular exosome nucleus Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9586 231991 Ensembl ENSG00000146592 ENSMUSG00000053007 UniProt Q02930 Q8K1L0 RefSeq (mRNA) NM_001011666 NM_004904 NM_182898 NM_182899 NM_172728 NM_001327821 RefSeq (protein) NP_001011666 NP_004895 NP_878901 NP_878902 NP_001314750 NP_766316 Location (UCSC) Chr 7: 28.3 – 28.83 Mb Chr 6: 53.26 – 53.68 Mb PubMed search [3] [4]
Wikidata
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The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1,^[8] and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]