CRELD1

Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene.^[5][6][7]

CRELD1
Identifiers
Aliases	CRELD1, AVSD2, CIRRIN, cysteine rich with EGF like domains 1
External IDs	OMIM: 607170; MGI: 2152539; HomoloGene: 32265; GeneCards: CRELD1; OMA:CRELD1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 9,933,822 bp[1] End 9,945,413 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.77 cM Start 113,460,258 bp[2] End 113,470,304 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum pituitary gland right lobe of thyroid gland anterior pituitary right uterine tube apex of heart right frontal lobe left lobe of thyroid gland primary visual cortex Brodmann area 9 Top expressed in transitional epithelium of urinary bladder decidua dentate gyrus of hippocampal formation granule cell olfactory tubercle superior frontal gyrus superior colliculus triceps brachii muscle primary visual cortex central gray substance of midbrain subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding extracellular matrix structural constituent Cellular component membrane integral component of membrane collagen-containing extracellular matrix Biological process endocardial cushion development cardiac septum development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 78987 171508 Ensembl ENSG00000163703 ENSMUSG00000030284 UniProt Q96HD1 Q91XD7 RefSeq (mRNA) NM_001031717 NM_001077415 NM_015513 NM_133930 RefSeq (protein) NP_001026887 NP_001070883 NP_056328 NP_001361245 NP_001361246 NP_001361247 NP_001361248 NP_001361249 NP_598691 Location (UCSC) Chr 3: 9.93 – 9.95 Mb Chr 6: 113.46 – 113.47 Mb PubMed search [3] [4]
Wikidata
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Function

Epidermal growth factor (EGF)-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of matricellular proteins.^[7]