CRIM1

Cysteine-rich motor neuron 1 protein is a protein that in humans is encoded by the CRIM1 gene.^[5][6]

CRIM1
Identifiers
Aliases	CRIM1, CRIM-1, S52, cysteine rich transmembrane BMP regulator 1 (chordin-like), cysteine rich transmembrane BMP regulator 1
External IDs	OMIM: 606189; MGI: 1354756; HomoloGene: 9510; GeneCards: CRIM1; OMA:CRIM1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.2 Start 36,355,778 bp[1] End 36,551,135 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2- E3 Start 78,507,677 bp[2] End 78,684,021 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein renal medulla superficial temporal artery lactiferous duct pericardium glomerulus germinal epithelium metanephric glomerulus urethra vena cava Top expressed in retinal pigment epithelium epithelium of lens decidua gastrula vestibular membrane of cochlear duct lateral geniculate nucleus medial dorsal nucleus intercostal muscle medial geniculate nucleus ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity PDZ domain binding insulin-like growth factor binding insulin-like growth factor-activated receptor activity serine-type endopeptidase inhibitor activity Cellular component integral component of membrane extracellular region plasma membrane membrane Biological process negative regulation of catalytic activity regulation of cell growth nervous system development negative regulation of endopeptidase activity insulin-like growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51232 50766 Ensembl ENSG00000277354 ENSG00000150938 ENSMUSG00000024074 UniProt Q9NZV1 Q9JLL0 RefSeq (mRNA) NM_016441 NM_015800 RefSeq (protein) NP_057525 NP_056615 Location (UCSC) Chr 2: 36.36 – 36.55 Mb Chr 17: 78.51 – 78.68 Mb PubMed search [3] [4]
Wikidata
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Function

Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival.^[5][6]

Clinical significance

Loss of Crim1 function as demonstrated by the Crim1 KST264 hypomorph mice resulted in onset of chronic kidney disease with accompanying pathology including papillary hypoplasia, functional urinary tract obstruction, ectopic collagen accumulation within the endothelium and tubulointerstitial fibrosis which was in part attributed by (endothelial) epithelial–mesenchymal transition.^[7][8]