CRLF3

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.^[5]

CRLF3
Identifiers
Aliases	CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDs	OMIM: 614853; MGI: 1860086; HomoloGene: 9327; GeneCards: CRLF3; OMA:CRLF3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 30,769,388 bp[1] End 30,824,692 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 47.43 cM Start 79,937,319 bp[2] End 79,971,817 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone mononuclear cell monocyte bone marrow blood lymph node epithelium of nasopharynx thymus bone marrow cells mucosa of sigmoid colon Top expressed in neural layer of retina granulocyte spleen blood mesenteric lymph nodes thymus tibiofemoral joint fetal liver hematopoietic progenitor cell bone marrow right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding DNA binding Cellular component plasma membrane cytoplasm cytosol nucleus Biological process negative regulation of cell growth positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of receptor signaling pathway via JAK-STAT G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51379 54394 Ensembl ENSG00000176390 ENSMUSG00000017561 UniProt Q8IUI8 Q9Z2L7 RefSeq (mRNA) NM_015986 NM_001277106 NM_018776 RefSeq (protein) NP_057070 NP_001264035 NP_061246 Location (UCSC) Chr 17: 30.77 – 30.82 Mb Chr 11: 79.94 – 79.97 Mb PubMed search [3] [4]
Wikidata
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Function

Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.^[6]

Origin

Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.^[7][8]