CROT (gene)

Peroxisomal carnitine O-octanoyltransferase is an enzyme that in humans is encoded by the CROT gene.^[5][6]

CROT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XL7, 1XL8, 1XMC, 1XMD
Identifiers
Aliases	CROT, COT, carnitine O-octanoyltransferase
External IDs	OMIM: 606090; MGI: 1921364; HomoloGene: 10899; GeneCards: CROT; OMA:CROT - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.12 Start 87,345,664 bp[1] End 87,399,794 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A1 Start 9,016,033 bp[2] End 9,047,324 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula jejunal mucosa mucosa of urinary bladder skin of thigh duodenum palpebral conjunctiva urethra hair follicle gingival epithelium epithelium of nasopharynx Top expressed in left lobe of liver right kidney human kidney epithelium of small intestine proximal tubule lacrimal gland jejunum esophagus duodenum ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity signaling receptor binding acyltransferase activity carnitine O-octanoyltransferase activity Cellular component intracellular membrane-bounded organelle peroxisome peroxisomal matrix cytosol Biological process medium-chain fatty acid metabolic process coenzyme A metabolic process lipid metabolism fatty acid transport generation of precursor metabolites and energy fatty acid metabolic process fatty acid beta-oxidation using acyl-CoA oxidase fatty acid beta-oxidation carnitine metabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54677 74114 Ensembl ENSG00000005469 ENSMUSG00000003623 UniProt Q9UKG9 Q9DC50 RefSeq (mRNA) NM_001143935 NM_001243745 NM_021151 NM_023733 RefSeq (protein) NP_001137407 NP_001230674 NP_066974 NP_076222 Location (UCSC) Chr 7: 87.35 – 87.4 Mb Chr 5: 9.02 – 9.05 Mb PubMed search [3] [4]
Wikidata
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Carnitine octanoyltransferase (EC 2.3.1.137) is a carnitine acyltransferase that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. This enzyme regulates the breakdown of Very Long Chain Fatty Acids (VLCFA) by performing a crucial step in the transport of medium length acyl chains out of the mammalian peroxisome to the cytosol and mitochondria for further breakdown. See also CRAT (MIM 600184). Van der Leij et al. (2000) reviewed the function, structural features, and phylogenetics of human carnitine acyltransferase genes, including CROT.[supplied by OMIM]^[6]