CRSP3

Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.^[5][6]

MED23
Identifiers
Aliases	MED23, ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2, mediator complex subunit 23
External IDs	OMIM: 605042; MGI: 1917458; HomoloGene: 3552; GeneCards: MED23; OMA:MED23 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 131,573,966 bp[1] End 131,628,242 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A4|10 Start 24,745,884 bp[2] End 24,789,579 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum Achilles tendon Epithelium of choroid plexus endometrium body of pancreas mucosa of paranasal sinus mucosa of sigmoid colon secondary oocyte pylorus epithelium of colon Top expressed in spermatocyte primitive streak secondary oocyte zygote genital tubercle tail of embryo Gonadal ridge primary oocyte ventricular zone ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding Cellular component nucleus transcription regulator complex nucleoplasm mediator complex Biological process regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of nucleic acid-templated transcription positive regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9439 70208 Ensembl ENSG00000112282 ENSMUSG00000019984 UniProt Q9ULK4 Q80YQ2 RefSeq (mRNA) NM_001270521 NM_001270522 NM_004830 NM_015979 NM_001166416 NM_027347 RefSeq (protein) NP_001257450 NP_001257451 NP_004821 NP_057063 NP_001363446 NP_001363447 NP_001363448 NP_001363449 NP_001363450 NP_001363451 NP_001363452 NP_001363453 NP_001159888 NP_081623 Location (UCSC) Chr 6: 131.57 – 131.63 Mb Chr 10: 24.75 – 24.79 Mb PubMed search [3] [4]
Wikidata
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Function

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[6]

Interactions

CRSP3 has been shown to interact with Estrogen receptor alpha,^[7] CEBPB^[8] and Cyclin-dependent kinase 8.^[7][9]