CRTC1

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.^[5][6][7][8] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands^[9] and various regions of the adult central nervous system.^[10]

CRTC1
Identifiers
Aliases	CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
External IDs	OMIM: 607536; MGI: 2142523; HomoloGene: 41607; GeneCards: CRTC1; OMA:CRTC1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,683,678 bp[1] End 18,782,333 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,835,005 bp[2] End 70,892,229 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell paraflocculus of cerebellum right hemisphere of cerebellum Brodmann area 10 middle frontal gyrus frontal pole cerebellar vermis right frontal lobe nucleus accumbens cingulate gyrus Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex genital tubercle lumbar subsegment of spinal cord tail of embryo neural layer of retina cerebellar cortex hippocampus proper zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cAMP response element binding protein binding Cellular component soma plasma membrane dendrite synapse nucleus nucleoplasm cytoplasm cytosol nuclear body postsynaptic density glutamatergic synapse Biological process positive regulation of CREB transcription factor activity viral process positive regulation of dendrite development memory entrainment of circadian clock by photoperiod protein homotetramerization positive regulation of long-term synaptic potentiation transcription, DNA-templated positive regulation of transcription by RNA polymerase II rhythmic process regulation of transcription, DNA-templated energy homeostasis negative regulation of membrane hyperpolarization postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23373 382056 Ensembl ENSG00000105662 ENSMUSG00000003575 UniProt Q6UUV9 Q68ED7 RefSeq (mRNA) NM_001098482 NM_015321 NM_025021 NM_001004062 RefSeq (protein) NP_001091952 NP_056136 NP_001004062 NP_001391344 NP_001391345 NP_001391346 NP_001391347 NP_001391348 NP_001391349 NP_001391350 NP_001391351 NP_001391352 NP_001391353 NP_001391354 NP_001391355 NP_001391356 NP_001391357 NP_001391358 NP_001391359 Location (UCSC) Chr 19: 18.68 – 18.78 Mb Chr 8: 70.84 – 70.89 Mb PubMed search [3] [4]
Wikidata
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Not to be confused with mTORC1.

Clinical significance

Production of CRTC1 is blocked in Alzheimer's disease.^[11]

See also

• Transcription coregulator