CRYGC

Crystallin, gamma C, also known as CRYGC, is a protein which in humans is encoded by the CRYGC gene.^[5][6]

CRYGC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NBR
Identifiers
Aliases	CRYGC, CCL, CRYG3, CTRCT2, crystallin gamma C
External IDs	OMIM: 123680; MGI: 88523; HomoloGene: 36281; GeneCards: CRYGC; OMA:CRYGC - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 208,128,137 bp[1] End 208,129,828 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C2|1 32.81 cM Start 65,110,684 bp[2] End 65,112,848 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad left testis right testis gastric mucosa duodenum hypothalamus islet of Langerhans C1 segment pituitary gland Top expressed in lens cornea corneal stroma urethra female urethra blastocyst male urethra epithelium of urethra epithelium of male urethra epithelium of female urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of eye lens Cellular component cytoplasm nucleus Biological process visual perception lens development in camera-type eye Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1420 12966 Ensembl ENSG00000163254 ENSG00000285011 ENSMUSG00000025952 UniProt P07315 Q61597 RefSeq (mRNA) NM_020989 NM_001082573 NM_007775 RefSeq (protein) NP_066269 NP_001076042 NP_031801 Location (UCSC) Chr 2: 208.13 – 208.13 Mb Chr 1: 65.11 – 65.11 Mb PubMed search [3] [4]
Wikidata
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Function

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.^[6]

Interactions

CRYGC has been shown to interact with CRYBB2,^[7] CRYAA^[7] and CRYAB.^[7]