CRYZ

Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.^[5]

CRYZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YB5
Identifiers
Aliases	CRYZ, crystallin zeta
External IDs	OMIM: 123691; MGI: 88527; HomoloGene: 133907; GeneCards: CRYZ; OMA:CRYZ - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 74,705,482 bp[1] End 74,733,408 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H4 Start 154,596,711 bp[2] End 154,623,182 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte renal medulla kidney tubule right lobe of liver corpus epididymis caput epididymis seminal vesicula gallbladder body of pancreas human kidney Top expressed in retinal pigment epithelium human kidney right kidney Epithelium of choroid plexus left lobe of liver iris pineal gland epithelium of lens ciliary body vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity zinc ion binding NADPH binding NADPH:quinone reductase activity NADH binding RNA binding mRNA 3'-UTR binding Cellular component cytosol extracellular exosome cytoplasm Biological process protein homotetramerization xenobiotic catabolic process visual perception Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1429 12972 Ensembl ENSG00000116791 ENSMUSG00000028199 UniProt Q08257 P47199 RefSeq (mRNA) NM_001130042 NM_001130043 NM_001134759 NM_001889 NM_009968 RefSeq (protein) NP_001123514 NP_001123515 NP_001128231 NP_001880 NP_034098 NP_001344601 NP_001344602 NP_001344603 NP_001344604 NP_001344605 Location (UCSC) Chr 1: 74.71 – 74.73 Mb Chr 3: 154.6 – 154.62 Mb PubMed search [3] [4]
Wikidata
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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.^[5]