CST2

Cystatin-SA is a protein that in humans is encoded by the CST2 gene.^[3]

CST2
Identifiers
Aliases	CST2, cystatin SA
External IDs	OMIM: 123856; GeneCards: CST2; OMA:CST2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 23,823,769 bp[1] End 23,826,729 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland decidua tongue seminal vesicula Thalamus thymus right adrenal cortex gallbladder olfactory zone of nasal mucosa gonad n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding protease binding cysteine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular space Biological process negative regulation of peptidase activity detection of chemical stimulus involved in sensory perception of bitter taste negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1470 n/a Ensembl ENSG00000170369 n/a UniProt P09228 n/a RefSeq (mRNA) NM_001322 n/a RefSeq (protein) NP_001313 n/a Location (UCSC) Chr 20: 23.82 – 23.83 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.^[3]